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주요 연구 논문 사례 : 항암 작용 효과                                                                                                                                                  Appendix







      EF-2001 살균유산균 항암작용 실험 결과 : SCI급 논문 등재




      EF-2001 유산균을 통한 Carcinoma / Sarcoma 암세포에 대한 효과 / IFN-γ, TNF-α  항암사이토 카인 분석 결과



       Carcinoma                                                            IFN-
                                                                                40                                   •  IFN-γ
                                                                                35                                   T림프구의 분열 촉진제
         600                                  8
              Control                                                           30
                                              7
         500                                                 Control
              EF-2001
                                              6              EF-2001            25                                   •  Trolox
         400                                  5                                                                      대표적 항산화제
        Tumor SIze (mm)  300               Tumor weight (g)  4               IFN-gamma (pg/mouse)  20                Tetramethylchroman 2 carboxylic acid
                                                                                15
         200
         100                                  3                                 10
                                              2
          0                                   1                                  5
             0   1    2   3   4    5
                       Week                   0                                  0
                                                                                           Control  EF-2001

       Sarcoma 180                                                          Anti-Oxidation
                                                                                0.9                                                       -Current Pharmaceutical Biotechnology 18, 653-661.
                                                                                0.8                                                       Pharmaceutical Production of Anti-tumor and Immune-potentiating
                                                                                                                                          Enterococcus faecalis EF-2001
          700                                  8                                0.7
               Control
          600                                  7               Control
               EF-2001                                                          0.6                                                       β-glucan: Enhanced Activity of Macrophage and Lymphocytes in
          500                                                  EF-2001                                                                    Tumor-implanted Mice (2017)
                                               6                                0.5
         Tumor SIze (mm)  300               Tumor weight (g)  5 4             Absorbance (520 nm)  0.4  Control
          400
                                                                                0.3
          200
          100                                  3                                0.2      Trolox
                                               2
           0                                                                    0.1      EF-2001
              0   1    2   3    4   5          1
                        Week                                                     0
                                               0                                      0        30       60      90       120      150
                                                                                                          Sample μL
   27   28   29   30   31   32   33   34   35